抗生素虽可以挽救生命，但长期使用抗生素可能会增加妇女患心脏病的几率。所以尽量在绝对需要抗生素的时候使用抗生素。考虑到潜在累积的不良反应，抗生素的使用时间越短越好。

关键词：科普、译文、抗生素、心脏病

Taking antibiotics for two months or longer may be linked to an increase in a woman’s risk for cardiovascular disease.

服用抗生素两个月或更久可能会增加女性患心血管疾病的风险。

Using antibiotics for two months or longer may be linked to an increase in a woman’s risk for cardiovascular disease.

使用抗生素两个月或更长时间可能会增加女性患心血管疾病的风险。

The finding, published in the European Heart Journal, applied to women who used the drugs when they were 40 and older.

该研究结果发表在《欧洲心脏杂志》上，适用于40岁及以上使用药物的女性。

Researchers used data on 36,429 women free of cardiovascular disease at the start of the study who were participating in a continuing long-term health study. Beginning in 2004, the women reported their use of antibiotics.

研究开始时，研究人员使用了36,429名无心血管疾病的妇女的数据，这些妇女参与了一项持续的长期健康研究。从2004年开始，这些妇女报告了她们使用抗生素的情况。

Over seven years of follow-up, there were 1,056 cases of cardiovascular disease. Compared with women who never used them, women who used antibiotics for two months or longer during their 40s and 50s had a 28 percent increased risk for cardiovascular disease, and women over 60 who used them that long had a 32 percent increased risk.

经过7年的随访，1,056人在此期间患上了心血管疾病。与从未使用过抗生素的女性相比，在40多岁和50多岁时服用抗生素两个月或更长时间的女性患心血管疾病的风险增加了28％，而使用抗生素两个月或更长时间的60岁以上的女性患心血管疾病的风险增加了32％。

The study controlled for family history of heart attack, body mass index, hypertension, the use of other medications and other factors.

该研究考察了心脏病发作家族史、体重指数、高血压、使用其他药物等因素。

“It’s difficult to distinguish the effect of the antibiotic on cardiovascular disease from the effect of the disease for which the antibiotic was taken, and that’s a potential limitation of the study,” said the lead author, Lu Qi, now a professor of epidemiology at Tulane University. “But that we are seeing the effect of the disease instead of the antibiotic is unlikely, because we see the effect in so many different diseases where antibiotics are used.”

“很难区分抗生素对心血管疾病的影响与服用抗生素的疾病的影响，这是该研究的潜在局限性，”该研究的主要作者、杜兰大学流行病学教授陆琦说。“但是我们看到的是疾病的影响而不是抗生素是不可能的，因为我们在使用抗生素的许多不同疾病中都看到了这种影响。”

（责任编辑：周姚）

（版权说明，转载自：微信公众号：科学猫科普）